Safety Alerts & Recalls

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Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS
Medco Health Solutions, a pharmacy benefit provider, recently identified a possible drug interaction between Plavix (clopidogrel) and proton pump inhibitors (PPIs), such as Aciphex, Nexium, Prevacid, Prilosec, or Protonix. In this study, patients taking Plavix together with a proton pump inhibitor had more heart and stroke problems than those who took Plavix alone. Plavix is most commonly used by patients who have had previous heart or stroke problems, and works by reducing platelet clotting activity ('thinning the blood'). PPIs are commonly used to treat heartburn by reducing acid production in the stomach. Examples of PPIs include over the counter medications such as Prilosec (omeprazole), and the prescription products Nexium (esomeprazole), Prevacid (lansoprazole), Protonix (pantoprazole), and Aciphex (rabeprazole). For more information please visit: http://circ.ahajournals.org/cgi/content/meeting_abstract/118/18_MeetingAbstracts/S_815?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=clopidogrel&searchid=1&FIRSTINDEX=0&volume=118&issue=18+Supplement&resourcetype=HWCIT
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Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS
Medco Health Solutions, a pharmacy benefit provider, recently identified a possible drug interaction between clopidogrel (Plavix) and esomeprazole (Nexium). In this study, patients taking Plavix together with a proton pump inhibitor (PPI), like esomeprazole (Nexium), had more heart and stroke problems than those who took Plavix alone. Plavix is most commonly used by patients who have had previous heart or stroke problems, and works by reducing platelet clotting activity ('thinning the blood'). PPIs are commonly used to treat heartburn by reducing acid production in the stomach. Examples of PPIs include over the counter medications such as Prilosec (omeprazole), and the prescription products Nexium (esomeprazole), Prevacid (lansoprazole), Protonix (pantoprazole), and Aciphex (rabeprazole). For more information please visit: http://circ.ahajournals.org/cgi/content/meeting_abstract/118/18_MeetingAbstracts/S_815?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=clopidogrel&searchid=1&FIRSTINDEX=0&volume=118&issue=18+Supplement&resourcetype=HWCIT
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Date Published Title Drug Source
2008-11-13 Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS Clopidogrel MediGuard CRT
2008-11-13 Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS Esomeprazole MediGuard CRT
2008-11-13 Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS Lansoprazole MediGuard CRT
2008-11-13 Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS Omeprazole MediGuard CRT
2008-11-13 Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS Pantoprazole MediGuard CRT
2008-11-13 Early Communication about Potential Drug Interaction Between PLAVIX and PROTON PUMP INHIBITORS Rabeprazole MediGuard CRT
2008-11-13 Update on FDA Safety Review of Bisphosphonates Alendronate FDA
2008-11-12 Nationwide Recall of Two Lots of Infants' Mylicon Gas Relief Dye Free Drops (Simethicone-Antigas) Simethicone FDA
2008-11-10 Recall on Several Lots of Propafenone 150 mg, 225 mg, and 300 mg Tablets Propafenone Manufacturer
2008-11-10 Recommendations for Antiplatelet Therapy (Aspirin, Clopidogrel, or Ticlopdipine) Ticlopidine MediGuard CRT
2008-11-10 Recommendations for Antiplatelet Therapy (Aspirin, Clopidogrel, or Ticlopdipine) Clopidogrel MediGuard CRT
2008-11-10 Recommendations for Antiplatelet Therapy (Aspirin, Clopidogrel, or Ticlopdipine) Aspirin MediGuard CRT
2008-11-10 Postmenopausal Hormone Therapy May Be Associated with Heartburn Estrogens Conjugated MediGuard CRT
2008-11-10 Postmenopausal Hormone Therapy May Be Associated with Heartburn Estradiol MediGuard CRT
2008-11-10 Postmenopausal Hormone Therapy May Be Associated with Heartburn Raloxifene MediGuard CRT
2008-11-10 Postmenopausal Hormone Therapy May Be Associated with Heartburn Tamoxifen MediGuard CRT
2008-11-10 New Safety Information about Long-term Use of Ipratropium (Atrovent) for COPD Ipratropium MediGuard CRT
2008-11-10 New Safety Information about Long-term Use of Ipratropium for COPD Albuterol Sulfate with Ipratropium Bromide MediGuard CRT
2008-11-10 Cholesterol-lowering Medications May Increase Risk of Confusion After Surgery Atorvastatin MediGuard CRT
2008-11-10 Cholesterol-lowering Medications May Increase Risk of Confusion After Surgery Simvastatin MediGuard CRT